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Inhibition of platelet aggregation by clopidogrel is entirely because of an active metabolite. Clopidogrel is metabolized to this Lively metabolite partly by CYP2C19. .cyclophosphamide will enhance the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.istradefylline will enh